Status:
COMPLETED
Regional Distribution Differences Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation
Lead Sponsor:
Boston Children's Hospital
Conditions:
Respiratory Failure
Eligibility:
All Genders
1-18 years
Brief Summary
Neurally adjusted ventilatory assist (NAVA) is an FDA approved mode of mechanical ventilation. This mode of ventilation is currently in routine use in adult, pediatric and neonatal intensive care unit...
Eligibility Criteria
Inclusion
- All intubated and mechanically ventilated patients in our intensive care units (ICUs) will be screened for the following inclusion criteria:
- Age: 1 month to 18 years.
- Mechanically ventilated for longer than 6 hours
- Either:
- Eligible for a spontaneous breathing mode of ventilation (not receiving chemical paralytics and has an appropriate spontaneous respiratory drive/rate given the size and condition of the patient) as determined by the team.
- or
- Currently in the pressure support ventilation (PSV) or neurally adjusted ventilatory assist (NAVA) mode of ventilation
Exclusion
- Patients in which a nasal gastric or oral gastric tube is contraindicated. Examples are but not limited to: s/p esophagus, tracheal surgery, bleeding disorders, facial trauma.
- Uncuffed endotracheal tube (ETT)
- Cervical-spine injury that prohibits rolling the patient for electrical impedance tomography (EIT) band placement.
- Difficult airway
- Congenital cyanotic heart defects
- Positive end expiratory pressure (PEEP) \> 15 cmH2O
- Fractional inspired oxygen concentration (FIO2) \> 0.8
- Peak inspiratory pressure (PIP) \> 30 cmH2O
- Patients who are receiving chemical paralysis
- History of prematurity (birth at post-conceptual age \<37 weeks)
Key Trial Info
Start Date :
May 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2020
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT01504373
Start Date
May 1 2011
End Date
April 1 2020
Last Update
November 16 2022
Active Locations (1)
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1
Children's Hospital Boston
Boston, Massachusetts, United States, 02115