Status:
COMPLETED
Effect of a Component of Fish Oil on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma
Lead Sponsor:
Indiana University
Collaborating Sponsors:
Pharmalink
Conditions:
Asthma
Exercise-Induced Bronchoconstriction
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
The primary aim of this study will be to evaluate the effects of Lyprinol® supplementation on airway inflammation and the bronchoconstrictor response to dry air hyperpnea in individuals with asthma. T...
Detailed Description
Our research group has shown, on numerous occasions that fish oil has a markedly protective effect in suppressing airway inflammation and exercise-induced bronchoconstriction in elite athletes and ast...
Eligibility Criteria
Inclusion
- Have been diagnosed with asthma and EIB. Evidence of a diagnosis of asthma will include medication use as well as history and symptoms as outlined in the NHLBI Guidelines for the Diagnosis and Management of Asthma. For the diagnosis of EIB, subjects must demonstrate a fall in FEV1 of ≥ 10% after dry air eucapnic voluntary hyperventilation (EVH), a simulated exercise challenge; FEV1 is a measure of lung function
- Not currently be taking any fish oil supplements
- Limit their fish consumption to 1 fish meal per week during the course of the study
Exclusion
- Severe asthma is indicated. These subjects will be identified by a post-EVH drop in FEV1 that is greater than 50% during their first lab testing session or will have a history of severe asthma-related events such as hospitalizations or emergency room visits. Only mild to moderate asthmatics (i.e. subjects whose FEV1 drops by 10-50%) will be included in this study.
- They taking currently taking asthma maintenance medications
- They are pregnant
- They have a history of hyperlipidemia (high cholesterol), hypertension, diabetes, bleeding disorder, delayed clotting time, or seizure disorder
- They are allergic to shellfish, fish, corn, or soy products
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01504646
Start Date
January 1 2012
End Date
August 1 2012
Last Update
October 23 2018
Active Locations (1)
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1
Indiana University School of Health, Physical Education, and Recreation
Bloomington, Indiana, United States, 47405