Status:
COMPLETED
Novel Methodology to Measure Protein Accumulation
Lead Sponsor:
Mayo Clinic
Conditions:
Aging
Eligibility:
All Genders
18+ years
Brief Summary
Accumulation of damaged proteins is thought to underlie many degenerative conditions, including aging, diabetes, Alzheimer's disease, cataracts, and others. Over time, proteins can be irreversibly dam...
Eligibility Criteria
Inclusion
- Age 18-30 years
- Age greater than 65 years
Exclusion
- Active or uncontrolled cardiovascular disease
- Chronic kidney disease with serum creatinine ≥ 1.4 mg/dL for women and ≥ 1.5 mg/dL for men
- Chronic liver disease (elevation in serum transaminases ≥ 3 times the upper limit of normal)
- Any debilitating chronic illness, including malignancy
- Significant malabsorptive state, including prior gastric bypass surgery or inflammatory bowel disease
- Diabetes mellitus (types 1 or 2) or glucose ≥ 110 mg/dL.
- Obesity (BMI ≥ 31 kg/m2)
- Anticoagulant therapy (warfarin or heparin) or bleeding disorder that increases risk of bleeding during a muscle biopsy.
- Anemia (hemoglobin ≤ 11 g/dL)
- Use of medications known to modulate protein synthesis, mitochondrial function, and/or glucose homeostasis (including β-blockers and corticosteroids).
- Participation in another study where the 13CPhe was administered during the past 6 months.
- Moderate or high level of structured exercise (on average, ≥ 30 minutes per day and ≥ 2 days per week)
- Pregnancy
- Daily use of tobacco products (smoking or chewing); or smoking ≥7 cigarettes per week, on average. Abstinence from tobacco for ≥3 months is required before enrollment in the study.
Key Trial Info
Start Date :
December 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01505621
Start Date
December 1 2011
End Date
August 1 2013
Last Update
April 10 2014
Active Locations (1)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905