Status:
COMPLETED
Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Conditions:
Nicotine Dependence
Eligibility:
All Genders
18-64 years
Brief Summary
Background: \- Researchers have been studying behavioral components of nicotine addiction by looking at how drugs have a reinforcing effect, connecting the stimulation provided by the drug (nicotine)...
Detailed Description
Objectives: 1) to compare the reinforcing efficacy of nicotine versus denicotinized cigarettes using a forced choice and an operant response procedure, 2) to compare the effects of smoking cues versus...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- 18-64 year old males and females
- smoking at least 10 cigarettes per day for at least 1 year
- urinary cotinine level greater than or equal to 100 ng/ml (NicAlert reading greater than or equal to 3)
- medically and psychologically healthy as determined by screening criteria
- EXCLUSION CRITERIA:
- definite plan to reduce or quit tobacco use in the next 30 days
- treatment for tobacco dependence in the past 3 months
- use of nicotine replacement products, bupropion, or varenicline in the past 3 months
- consumption of more than 15 alcoholic drinks per week during the past month
- use of any illicit drug more than twice per week during the past month
- current use of any medication that would interfere with the protocol in the opinion of MAI
- under the influence of a drug or alcohol at experimental sessions
- pregnant, nursing, or become pregnant during the study
Exclusion
Key Trial Info
Start Date :
March 16 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 29 2013
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT01505725
Start Date
March 16 2010
End Date
November 29 2013
Last Update
April 5 2018
Active Locations (1)
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1
National Institute on Drug Abuse, Biomedical Research Center (BRC)
Baltimore, Maryland, United States, 21224