Status:
WITHDRAWN
ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Obsessive Compulsive Disorder
Major Depressive Disorder
Eligibility:
All Genders
18-70 years
Brief Summary
The investigators propose a test of causality by examining a cohort of patients undergoing deep brain stimulation (DBS) within the ventral striatum. The investigators will examine behavior on and off ...
Detailed Description
The study will take place at a clinical office in the Charlestown Navy Yard (CNY), and will consist of 4 or 4.5 hour visit. Study staff will schedule a convenient time for patients to arrive, or the r...
Eligibility Criteria
Inclusion
- DBS Patients:
- Deep brain stimulator implantation performed at least three months prior to study
Exclusion
- Subjects unable to visualize stimulus objects with correction
- Dementia or other known cognitive deficit
- Psychiatric Patients:
- Inclusion Criteria:
- Right-handed (as determined by the Handedness Inventory; Oldfield, 1971)
- Normal or corrected-to normal vision and hearing
- Current diagnosis of MDD or OCD
- Exclusion Criteria for Patients:
- Clinical history of bipolar disorder
- Current or past psychotic disorder
- Gross structural brain damage
- Cognitive impairment that would affect a participant's ability to give informed consent
- Current substance abuse, or abuse within the past 3 months
- Clinical history of severe personality disorder
- Imminent risk of suicide or an inability to control suicide attempts
- Evidence of dementia or other significant cognitive impairment on neuropsychological evaluation
Key Trial Info
Start Date :
February 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 10 2024
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01506206
Start Date
February 1 2012
End Date
January 10 2024
Last Update
January 23 2024
Active Locations (2)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
2
Massachusetts General Hospital
Charlestown, Massachusetts, United States, 02129