Status:
COMPLETED
Sublingual Immunotherapy in Children With Allergic Rhinitis
Lead Sponsor:
Federal University of Uberlandia
Collaborating Sponsors:
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Conditions:
Allergic Rhinitis
Eligibility:
All Genders
5-15 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the clinical efficacy and mucosal/systemic antibody response changes after SLIT using house dust mite allergen with or without bacterial extracts in mite-aller...
Detailed Description
Patients with allergic rhinitis with or without asthma were selected for a randomized double-blind, placebo-controlled trial and distributed into three groups: DPT (Dpt allergen extract, n=34), DPT+MR...
Eligibility Criteria
Inclusion
- Clinical diagnosis of allergic rhinitis
- Positive skin test to Dermatophagoides pteronyssinus total extract
- Positive serum levels of specific IgE to D. pteronyssinus extract
Exclusion
- Previous allergen immunotherapy
- Use of antihistamines 1 week or topical corticosteroid up to 3 weeks prior to skin prick test
- Long term use of systemic corticosteroid.
- Airway infection 30 days prior to the selection.
- Children with severe asthma, malignant, cardiovascular or autoimmune diseases, under chemotherapy or immunosuppressor therapy.
- Users of cigarette smoke
- Presence of severe skin lesions
Key Trial Info
Start Date :
October 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
122 Patients enrolled
Trial Details
Trial ID
NCT01506843
Start Date
October 1 2008
End Date
April 1 2011
Last Update
January 10 2012
Active Locations (1)
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1
Asthma and Rhinitis Control Program
Itumbiara, Goiás, Brazil, 75503-520