Status:
COMPLETED
Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Body Mass Index ≥ 27
Lead Sponsor:
Les Laboratoires des Médicaments Stériles
Collaborating Sponsors:
University Hospital Fattouma Bourguiba
Conditions:
Cardiovascular Disease
Overweight
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
The purpose of the study is to determine whether administration of 150 mg clopidogrel is effective in reducing the one-year incidence of thromboischemic events in patients with high on-clopidogrel pla...
Detailed Description
The goal is to evaluate the effect of the double maintenance dose of clopidogrel versus single dose in patients with proven coronary and with BMI ≥ 27 kg.m-2 1 - Biologically: study and compare the re...
Eligibility Criteria
Inclusion
- Male or female,
- Old (e) of more than 20 years
- BMI ≥ 27kg.m-2
- Patients hospitalized for acute coronary syndrome (Whatever the ST segment and troponin dosage)
- Patients with proven coronary candidates for treatment with Clopidogrel (who received a loading dose of 600mg over 2 hours or treated with 75 mg/day or 150mg / day of clopidogrel for longer than 7 days)
Exclusion
- Patients unwilling.
- Patient participating in another study.
- Patients with cardiogenic shock
- Patient on anti GpIIbIIIa or stopped less than 72 hours before the test aggregability
- Patients scheduled for surgery in less than 6 months
- ischemic stroke older than 6 weeks.
- History of hemorrhagic stroke (any time)
- Patients on or candidates for AVK
- Patients with a different anti ADP (ticlopidine, prasugrel)
- Patients with an indication against clopidogrel (side effects, bleeding ...)
- Thrombocytopenia \< 100000/mm3
- anemia (Ht \< 30%)
- Thrombocythaemia (Ht \> 52%)
- Pregnancy
Key Trial Info
Start Date :
December 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
116 Patients enrolled
Trial Details
Trial ID
NCT01509365
Start Date
December 1 2011
End Date
May 1 2015
Last Update
May 7 2015
Active Locations (1)
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1
cardiology department, hospital Fattouma Bourguiba
Monastir, Monastir Governorate, Tunisia, 5000