Status:
COMPLETED
Efficacy of Low Dose hCG on Oocyte Maturity in Poor Responder Women Undergoing Intracytoplasmic Sperm Injection
Lead Sponsor:
Royan Institute
Conditions:
Infertility
Eligibility:
FEMALE
37-43 years
Phase:
PHASE3
Brief Summary
This study is a prospective, randomized, parallel, controlled trial to assess the efficacy of the late follicular phase administration of low dose hCG on oocyte maturity for ovarian stimulation in 73 ...
Detailed Description
In this study all eligible patients were randomly allocated into three study groups by a permuted block randomization method: group A (control group) received only recombinant FSH, group B received rF...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Poor ovarian response to ovulation induction according to the ESHRE definition\[20\] and presence of at least 2 of the criteria needed to define poor responders including advanced maternal age, history of low ovarian response in previous IVF/ICSI treatments and abnormal ovarian reserve test(Antral Follicle number \< 5)
- indication for ICSI treatment, second or third cycle
- Age 37 to 43 years
- Body mass index (BMI) ≤ 30 kg/m2
- The presence of two functional ovaries and no previous ovarian surgery
- The presence of normal uterine cavity and 2 normal tubes base on recent hysterosalpingographic or hysteroscopic evaluation
- Basal (day 2 or 3) serum FSH levels ≤13 IU/L
- Normal semen analysis
- No history or signs of endometriosis
- No untreated endocrinologic disease
Exclusion
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
73 Patients enrolled
Trial Details
Trial ID
NCT01509833
Start Date
October 1 2009
End Date
December 1 2011
Last Update
January 13 2012
Active Locations (1)
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1
Royan Institute
Tehran, Iran