Status:
COMPLETED
Cyproheptadine and Chlorpromazine Effects on Spasticity
Lead Sponsor:
University of Alberta
Conditions:
Spinal Cord Injuries
Muscle Spasticity
Eligibility:
All Genders
17+ years
Brief Summary
The main goal of this research is to understand the neuronal mechanisms that mediate the development of spasticity and motor dysfunction after spinal cord injury. The investigators examine how neurons...
Eligibility Criteria
Inclusion
- Patients must have suffered a trauma to the spinal cord at least 6 months ago or longer. In addition, subjects must exhibit some degree of spasticity as determined by having an Ashworth Spasticity Score, as assessed by a physical therapist, greater than 1.
Exclusion
- If patients have damage to the nervous system other than to the spinal cord
- Pregnant women
- Elderly Patients and debilitated patients
- Alcoholic Patients
- Patients with:
- Known or suspected allergy to the medication or its ingredients
- Cardiovascular disease
- Hypotension
- Coronary artery disease
- Reduced liver or kidney function
- Comatose or depressed states due to CNS depressants
- Blood dyscrasias
- Bone marrow depression
- History of seizures
- Respiratory problems
- Hypocalcemia
- Monoamine oxidase inhibitor therapy
- Angle-closure glaucoma
- Stenosing peptic ulcer
- Symptomatic prostatic hypertrophy
- Bladder neck obstruction
- Pyloroduodenal obstruction
- History of bronchial asthma
- Increased intraocular pressure
- Hyperthyroidism
- Cardiovascular disease
- Hypertension
- Patients taking:
- Amphetamines
- Antihistamines-second generation
- Anticonvulsants
- Anticholinergics
- CNS depressants
- Antidepressants
- Hypotensive agents
- Levodopa
- Lithium
Key Trial Info
Start Date :
July 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2012
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01509885
Start Date
July 1 2010
End Date
November 1 2012
Last Update
November 20 2012
Active Locations (1)
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1
University of Alberta
Edmonton, Alberta, Canada, T6G2R3