Status:
COMPLETED
Studying Biomarkers in Samples From Patients With High-Risk Neuroblastoma
Lead Sponsor:
Children's Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Neuroblastoma
Eligibility:
All Genders
Up to 30 years
Brief Summary
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer....
Detailed Description
OBJECTIVES: * To establish telomere length measurement by quantitative polymerase chain reaction (qPCR) as an alternative lengthening of telomeres (ALT) detection method in neuroblastoma (NB). * To d...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Snap-frozen neuroblastoma (NB) tumors collected at diagnosis (Objectives 1 to 3)
- High-risk stage 3 or 4 NB AND MYCN non-amplified, i.e., exclude stage 4 infants who are not high-risk
- Up to five high-risk (\> 18 months, unfavorable histology) stage 3/MYCN non-amplified tumors
- Patients preferably treated on protocol COG-A3973 or similar protocols with myeloablative therapy
- At least 3 years of follow-up for those with no event (current evidence suggests that ALT+ NBs often relapse late, i.e., 2 years or longer from diagnosis)
- NB tumor DNA collected at diagnosis (Objectives 2 \& 3)
- High-risk stage 3 or 4 NB as for Objective 1, except for MYCN status
- Stage 4 tumors are preferred; may include up to seven high-risk stage 3 tumors with similar distribution of MYCN-amplified and non-amplified tumors
- Frozen serum from NB patients (Objective 5; 2nd stage of project)
- Paired serum obtained at diagnosis from patients with ALT+ or ALT- tumors identified in Objective 2
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
January 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2016
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT01510600
Start Date
January 1 2012
End Date
May 1 2016
Last Update
May 19 2016
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