Status:
COMPLETED
Structural Connectivity as Imaging Endophenotypes of Autism Spectrum Disorders
Lead Sponsor:
National Taiwan University Hospital
Collaborating Sponsors:
National Science and Technology Council, Taiwan
Conditions:
Autism Spectrum Disorders
Eligibility:
MALE
10-15 years
Brief Summary
Autism spectrum disorders (ASD) is a highly hereditary neuropsychiatric disorder. In children and adolescents worldwide, the prevalence of ASD is estimated at 0.6%. Understanding the biological mechan...
Eligibility Criteria
Inclusion
- 20 males, right handed, age 10-15 years old. Diagnosis of high-functioning autism is made according to the DSM-IV and ICD-10 criteria by senior child psychiatrists experienced in autism assessments and treatments. The patients should have full-scale IQ ≧ 80 and no comorbid diseases.
- 20 unaffected (discordant) male siblings of patients with high-functioning autism
- 40 healthy school boys without any psychiatric disorders in the 1st and 2nd degree relatives. The patient group (N=20) and a neurotypical group (N=20) are matched in age,gender and handedness. The family group (N=20) and another neurotypical group (N=20) are matched in age, gender and handedness.
Exclusion
- full-scale IQ \< 80 and with comorbid diseases
- large imaging motion artifact
Key Trial Info
Start Date :
October 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 30 2012
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01513629
Start Date
October 1 2010
End Date
September 30 2012
Last Update
September 2 2021
Active Locations (1)
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1
Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine
Taipei, Taiwan, 10002