Status:
WITHDRAWN
An Initial Feasibility Study to Integrate MRI Based Brachytherapy and CT/MR Fused INRT in Treatment of Advance Cervical Cancer
Lead Sponsor:
AHS Cancer Control Alberta
Collaborating Sponsors:
Cross Cancer Institute
Conditions:
Integrated MRI Based RT as Standard of Care
Locally Advanced Cervical Cancer
Eligibility:
FEMALE
18-70 years
Phase:
PHASE1
Brief Summary
Main cause of mortality in cervix cancer is local relapse in the pelvis. Since distant metastasis is quiet rare, increasing local control in the pelvis can directly translate into improvement in survi...
Detailed Description
A total of 10 patients with a diagnosis of locally advanced cervical carcinoma will be enrolled. After diagnosis and written informed consent, patients will undergo investigations prior to treatment p...
Eligibility Criteria
Inclusion
- Cancer of the uterine cervix considered suitable for curative treatment with definitive radio-chemo-therapy including MRI guided BT. (stage IB2 bulky disease-stage IVa)
- Staging according to FIGO and TNM guidelines
- Positive biopsy showing squamous cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix
- No pelvic nodes \> 2cm
- MRI of pelvis at diagnosis
- MRI of the retroperitoneal space and abdomen at diagnosis
- MRI with applicator in place at time of BT
- Age 18-70 years
- Patient informed consent
Exclusion
- Pelvic nodes \> 2cm
- Previous pelvic or abdominal radiotherapy
- Previous total or partial hysterectomy
- Combination of preoperative radiotherapy with surgery
- Patients receiving neo-adjuvant chemotherapy
- Patients receiving BT only
- Contraindications to MRI
Key Trial Info
Start Date :
November 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2011
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01514955
Start Date
November 1 2009
End Date
December 1 2011
Last Update
February 25 2016
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