Status:
COMPLETED
Ulinastatin's Anti-inflammatory Reaction in Cardiac Surgery
Lead Sponsor:
Konkuk University Medical Center
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
25-75 years
Phase:
PHASE4
Brief Summary
The purpose of the present study is to determine whether ulinastatin, urinary anti-trypsin inhibitor, attenuates cardiopulmonary bypass (CPB)-activated systemic inflammatory response in cardiac surger...
Detailed Description
Applying aortic cross-clamp (ACC) and cardiopulmonary bypass (CPB) for cardiac surgery produces variable systemic inflammatory reactions. As a common complication of those reactions, pulmonary dysfunc...
Eligibility Criteria
Inclusion
- elective cardiac surgery employing CPB
Exclusion
- urgent/emergency surgery,
- previous heart surgery,
- combined CABG and valve surgery,
- age \> 75 yrs,
- left ventricular ejection fraction \< 0.45,
- diabetes treated with insulin,
- active gastropathic disorder,
- treatment for chronic obstructive pulmonary disease,
- preoperative use of steroids
- postoperative re-operation due to bleeding control
- pre and postoperative renal replacement therapy
- left ventricular assist device implantation
Key Trial Info
Start Date :
March 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT01518569
Start Date
March 1 2008
End Date
August 1 2008
Last Update
January 26 2012
Active Locations (1)
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1
Konkuk University Medical Center
Seoul, Seoul, South Korea, 143-729