Status:
COMPLETED
Comparison of Cardiac Imaging Techniques for Diagnosing Coronary Artery Disease
Lead Sponsor:
Amsterdam UMC, location VUmc
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
40+ years
Brief Summary
A large number of cardiac catheterizations are performed each year, primarily to diagnose heart disease. However, a cardiac catheterization is an invasive procedure which is associated with serious co...
Detailed Description
Coronary artery disease (CAD) remains the leading cause of morbidity and mortality in Western civilized countries. Early detection of CAD allows optimal therapeutic management in order to decrease mor...
Eligibility Criteria
Inclusion
- First presentation to cardiologist with suspected coronary artery disease
- No documented prior history of coronary artery disease
- Intermediate pre-test likelihood for coronary artery disease as defined by Diamond and Forrester criteria
- Clinically referred for invasive coronary angiography
- Age above 40 years
Exclusion
- History of severe chronic obstructive pulmonary disease (COPD) or chronic asthma
- Pregnancy
- Renal failure ( i.e. estimated glomerular filtration rate \< 45 mL/min)
- Use of sildenafil (Viagra) or dipyridamole (Persantin) that can not be terminated.
- Contra-indications for β-blockers
- Allergic reaction to iodized contrast
- Concurrent or prior (within last 30 days) participation in other research studies using investigational drugs
- Claustrophobia
- Significant co-morbidities
- Atrial fibrillation, second or third degree atrioventricular block
- Tachycardia
- Acute myocardial infarction
- Heart failure
- Left ventricle ejection fraction estimated \< 50%
- Cardiomyopathies
- Previous radiation exposure in the diagnostic work-up
- Subjects intended for short-term medical treatment or an invasive coronary intervention
- No informed consent
Key Trial Info
Start Date :
January 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT01521468
Start Date
January 1 2012
End Date
December 1 2014
Last Update
December 10 2014
Active Locations (1)
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1
VU University Medical Center
Amsterdam, Netherlands, 1081 HV