Status:
COMPLETED
Study to Determine if Using Ventilation During Open Heart Surgery Improves Lung Outcomes
Lead Sponsor:
Aurora BayCare Medical Center
Conditions:
Coronary Artery Disease
Heart Failure
Eligibility:
All Genders
Phase:
NA
Brief Summary
To demonstrate that using continuous mechanical lung ventilatory support in combination with Positive End Expiratory Pressure (PEEP)during open heart surgery will improve lung function and decrease lu...
Detailed Description
This is a prospective, randomized, blinded study with a control group. The study group will receive mechanical ventilatory support during CBB, which consists of a preset/predetermined tidal volume, re...
Eligibility Criteria
Inclusion
- any patient of any gender, any age with known coronary artery disease that will undergo elective Coronary Artery Bypass Grafting (CABG) and will require CPB as part of his/her operative technique.
Exclusion
- documented ejection fraction (either by echocardiogram or by cardiac catheterization) equal to or below 20%
- patients with cardiac valvular disease
- patients with a spirometry measurement that demonstrates an FEV1/FVC ratio below 60%
- patients with chronic renal failure who require dialysis or
- those who have experienced an allergic reaction to anesthesia in the past
- patients with a history of lung infiltrate on chest X-ray prior to surgery or a history of asthma
- Women who are pregnant are excluded
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 29 2015
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01522222
Start Date
July 1 2010
End Date
September 29 2015
Last Update
December 14 2018
Active Locations (1)
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1
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311