Status:
COMPLETED
Effects of Whole Sprouts on Airway Allergic Inflammation
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Allergic Rhinitis
Asthma
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The primary objective of this study is to determine if broccoli sprouts (BS) improves airway inflammatory, oxidative stress (OS), and symptoms among asthmatic adults with aeroallergen sensitization. ...
Eligibility Criteria
Inclusion
- doctor diagnosis of asthma
- aeroallergen sensitization
- Non-smoker
- Negative pregnancy test
- Not breastfeeding
- Normal TSH
- For women, abstinent or using reliable birth control
- Age 18-50 years
- No other major pulmonary disease such as cystic fibrosis or COPD
- Willingness to participate in study and sign consent form
Exclusion
- Severe or unstable asthma defined as requiring hospitalization in the previous 6 months or intubation in the previous 2 years, or on high-dose inhaled corticosteroids or chronic oral corticosteroids
- Uncontrolled asthma defined as short-acting beta agonist use 3 or more days a week in the previous 4 weeks
- Other significant medical issues such as heart disease or poorly controlled hypertension, type 1 diabetes, poorly controlled type 2 diabetes, or hypothyroidism
- Pregnancy or nursing/breastfeeding mothers
- On beta-blocker therapy
- On reserpine, clonidine, imipramine, or related tricyclic drugs
- Taking anti-oxidant supplements
- Planned dietary changes during the study period
- Unable to stop antihistamines prior to skin testing
- Food allergy to Broccoli Sprouts or Alfalfa Sprouts
- Omalizumab use within the last 12 months
- Nasal polyps
Key Trial Info
Start Date :
March 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT01522703
Start Date
March 1 2012
End Date
March 1 2015
Last Update
January 19 2017
Active Locations (1)
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1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21202