Status:
COMPLETED
Impact of Muscle Afferent Feedback During Exercise in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Lead Sponsor:
Laval University
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
MALE
55-75 years
Phase:
NA
Brief Summary
Recently, direct evidences point to the contributing role of peripheral muscle fatigue in exercise tolerance among patients with COPD. However, the physiological mechanisms by which peripheral muscle ...
Detailed Description
The aim of the study is to characterize the role of peripheral muscle afferents on the development of muscle fatigue, cardiorespiratory response and exercise tolerance to constant-workrate endurance c...
Eligibility Criteria
Inclusion
- Smoking history \> 15 pack-years
- COPD GOLD II-III (30 % predicted \< FEV1 \< 80 % predicted; FEV1/FVC \< 0.70)
Exclusion
- Unstable condition
- Recent exacerbation (\<3 months)
- Recent cancer (\<3 months)
- Myopathy, neuromuscular disease
- Unstable cardiac disease
- Hepatic, kidney, intestinal disease
- BMI \> 35
- PaCO2 \> 45 mmHg
- PaO2 \< 60 mmHg
Key Trial Info
Start Date :
October 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT01522729
Start Date
October 1 2010
End Date
January 1 2012
Last Update
February 1 2012
Active Locations (1)
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1
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Quebec, Canada, G1V 4G5