Status:
NO_LONGER_AVAILABLE
Efficacy of Parecoxib on Patients With CRPS
Lead Sponsor:
Ruhr University of Bochum
Conditions:
Causalgia
Eligibility:
All Genders
18+ years
Brief Summary
The complex regional pain syndrom is a weighty disease that often results in a lifelong disability. Mostly this disease appears unilateral after comparatively mundane fractures or operations. In early...
Eligibility Criteria
Inclusion
- Patients with saved diagnosis of CRPS of the upper extremity based on the current used criteria for diagnosis plus a positiv 3-phase-sceletal-scintilgraphy, if they show pathological PPT-values in QST on the ipsilateral site (Z-values \> 2 in age- and gender-based Z-transformation of the raw values)• age ≥ 18 years• Existence of an age-based normal creatinin-clearance (calculated with a defined formula)
Exclusion
- Important cardiovascular illness for the purpose of heart failure (NYHA II - IV), coronary heart disease (CHD), peripheral artery occlusive disease (PAOD) or unstable hypertension (values constantly over 140/90 mm Hg)
- Florid kidney disease
- Cerebral disease
- Neurological systemic disorder (exception: beginning polyneuropathy with normal values of the PPT on the opposite side)
- Lesion of the median nerve (ipsi- oder contralateral)
- Acute bleeding disease
- Known ulcer of the stomach or duodenum
- Inflammatory bowel disease
- Positive anamnesis of a gastrointestinal bleeding in the last 5 years
- Important hepatic dysfunction (Child- pugh \> 9)
- Hypersensitivity to the agent or to sulfonamides
- Known allergy to acetylsalicylic acid, nonsteroidal antiinflammatory drugs or other selectiv cyclooxygenase-inhibitors
- Pregnancy and lactation period
- Intake of one of the following drugs (current or in the last 3 days)
- selective-serotonin-reuptake-inhibitor
- cetoconazole
- rifampicin
- phenytoin
- carbamazepine
- dexamethasone or other systemic corticoids
- traditional nonsteroidal antiphlogistics
- cyclooxygenase-inhibitors
- immunsupressives
- TNF-α-inhibitors
Key Trial Info
Start Date :
Trial Type :
EXPANDED_ACCESS
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01523379
Last Update
April 25 2012
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