Status:
COMPLETED
Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure
Lead Sponsor:
United Christian Hospital
Conditions:
Chronic Obstructive Pulmonary Disease
Hypercapnic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The investigators design a pilot randomised, single-centred, controlled trial to compare different withdrawal methods of Non-invasive ventilation. Our study aims at comparing stepwise withdrawal of No...
Detailed Description
All patients would receive standard medical treatment with inhaled bronchodilator, systemic steroid, antibiotics according to our local bacteriology. Acute NIV was initiated by trained respiratory nur...
Eligibility Criteria
Inclusion
- COPD patients with AHRF requiring NIV
- the patient is cooperative with NIV treatment
- the patient is willing to give their written informed consent to participate in the study
- patient is stabilised after acute treatment after NIV as evidenced by ALL of the below::
- normalisation of arterial pH
- clinical stability as evidenced by
- SpO2 \> 88% on 2LO2 or less
- respiratory rate \< 25
- heart rate \< 120 bpm
- systolic blood pressure \> 90 mmHg
- patient not in agitation, diaphoresis or anxiety
Exclusion
- patients with non-COPD causes of AHRF, for example, chest infection and heart failure
- patients who are currently on home NIV
- patients who have contraindications to NIV and those who refused or failed NIV during an initial 15 minutes acclimatization period
- other significant co-morbid conditions that in the investigators' view , would confer an adverse prognosis during the study period
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01523470
Start Date
November 1 2010
End Date
October 1 2011
Last Update
February 1 2012
Active Locations (1)
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1
Department of Medicine, United Christian Hospital, Hong Kong
Hong Kong, Hong Kong