Status:
COMPLETED
The Effect of Prophylactic Antiemetic Dexamethasone on Plasma Cortisol Levels
Lead Sponsor:
William Li Pi Shan
Conditions:
Postoperative Nausea and Vomiting
Eligibility:
FEMALE
18-80 years
Phase:
NA
Brief Summary
Dexamethasone is a synthetic corticosteroid that has been proven to be effective and relatively safe for the prophylaxis of the postoperative nausea and vomiting (PONV). However, little is known abou...
Detailed Description
Hypothesis: The investigators hypothesize that preoperative administration of intravenous dexamethasone in non-cancer gynecologic laparotomy will decrease postoperative cortisol levels in a dose-depe...
Eligibility Criteria
Inclusion
- Women between 18 and 80 years-old scheduled for non-oncologic gynecologic laparotomy, including fibroid myomectomy, hysterectomy and endometrioma resection
Exclusion
- Communication barrier rendering informed consent inadequate
- Pregnancy
- Diabetes mellitus
- Chronic or acute renal failure
- Chronic or acute hepatic failure
- History of chronic opioid use
- History of corticosteroid use more than 3 weeks in the last 6 months (inhaled, oral or intravenous)
- History of disorders of the hypothalamus, pituitary gland and/or adrenal glands
- History of depression and/or bipolar disorder
- History of allergy or sensitivity to dexamethasone or any medication used in the standardised anesthetic care
- American Society of Anesthesiologists Physical Status class of 3 and above.
Key Trial Info
Start Date :
May 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2014
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT01524731
Start Date
May 1 2012
End Date
February 1 2014
Last Update
September 4 2014
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
McGill University Health Centre-Royal Victoria Hospital
Montreal, Quebec, Canada, H3A 1A1
2
Royal Victoria Hospital
Montreal, Quebec, Canada, H3A 1A1