Status:
COMPLETED
Rectal Cancer: Local Staging, Re-staging and Assessment of Lymph Nodes Using Pet-Ct, CT-Perfusion and 3T MRI
Lead Sponsor:
London Health Sciences Centre
Conditions:
Rectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate the accuracy of Positron emission tomography, Computed Tomography perfusion and 3 Tesla MRI in the radiological down-staging of rectal cancer following neoadju...
Detailed Description
Patient Recruitment: 30 consecutive patients with histologically-proven, non-mucinous rectal cancer will be recruited and stratified into three separate groups as follows: * T2 tumors (requiring onl...
Eligibility Criteria
Inclusion
- Rectal cancer, stage T2, T3, T4
Exclusion
- Rectal cancer, stage T1 or metastatic
- Non-rectal primary cancer invading the rectum
- Mucinous histology
- Patient is initially, or becomes a non-surgical candidate during the course of the study
- Hip prosthesis (affects PET-CT image processing)
- Allergy to CT contrast or patients with impaired renal function, defined as estimated glomerular filtrate rate (eGFR)\< 30 ml/min
- Prior radiotherapy to the region of the study that would result in overlap of radiation fields
- Contraindications to MRI
- Pregnancy
Key Trial Info
Start Date :
March 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01525056
Start Date
March 1 2012
End Date
September 1 2014
Last Update
September 9 2014
Active Locations (1)
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1
London Regional Cancer Program
London, Ontario, Canada, N6A4L6