Status:
COMPLETED
Improving Learning-based Treatment of Cocaine Dependence With Medication
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
COCAINE-RELATED DISORDERS
Eligibility:
All Genders
18-60 years
Phase:
PHASE2
Brief Summary
This study will test the efficacy of d-cycloserine in enhancing response to learning-based treatment for cocaine dependence, specifically contingency management.
Detailed Description
Cocaine dependence is a public health problem with substantial morbidity, however no effective pharmacotherapy for cocaine dependence has been approved by the FDA. Unlike previous medication studies t...
Eligibility Criteria
Inclusion
- 18-60 years of age (\> 60 due to age-related effects on cognitive functioning)
- Satisfy DSM-IV criteria for cocaine dependence (primarily crack)
- Able to complete all study measures
- Currently seeking treatment for cocaine dependence
Exclusion
- Meets DSM-IV criteria for dependence on a drug other than cocaine or nicotine (may meet abuse criteria for other drugs)
- Pregnant, breast feeding, or planning to become pregnant within 3 months
- If female, do not agree to use an effective means of birth control during the course of treatment (via phone screen)
- History of seizure disorder, severe hepatic impairment, porphyria, serious head trauma, dementia, or significant cognitive impairment
- Diagnosis of current major psychiatric disorder besides substance dependence or abuse
- Reported use of DCS in the past year
- Illiteracy, as will be determined during in-person screening
- Concurrently prescribed or using ethionamide or isoniazid (both used to treat tuberculosis)
- Positive urine result for opioids at screening interview
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT01526538
Start Date
September 1 2011
End Date
March 1 2013
Last Update
February 15 2017
Active Locations (1)
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1
Behavioral Pharmacology Research Unit
Baltimore, Maryland, United States, 212124