Status:
COMPLETED
A Comparison Between Propofol-Remifentanil and Midazolam-Remifentanil Sedation in the Intensive Care Unit
Lead Sponsor:
Yonsei University
Conditions:
Sedation
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare propofol-remifentanil sedation with midazolam-remifentanil sedation in regards to extubation and weaning time, length of stay in the ICU, as well as the inciden...
Detailed Description
With on-going emphasis on early extubation, as well as further recognition of morbidity and mortality associated with delirium, the specific sedatives and analgesics used in the ICU is an issue of int...
Eligibility Criteria
Inclusion
- surgical patients over 18 years old who were admitted to the ICU for postoperative ventilator care after sevoflurane-remifentanil based general anesthesia
Exclusion
- pre-existing neurologic dysfunction (dementia)
- head trauma patients
- previous history of alcohol abuse or substance abuse
- patients who had baseline serum creatinin levels of over 2.5mg/100ml
- uncompensated liver cirrhosis
- hemorrhagic, cardiogenic, or septic shock
- pregnancy or breast feeding
- tracheostomy or extubation before ICU admission.
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
77 Patients enrolled
Trial Details
Trial ID
NCT01527903
Start Date
September 1 2009
End Date
June 1 2010
Last Update
August 17 2016
Active Locations (1)
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1
Severance Hospital
Seoul, South Korea, 120-752