Status:

UNKNOWN

Vitamin D Metabolism in Chronic Kidney Disease Patients

Lead Sponsor:

Memphis VA Medical Center

Conditions:

Vitamin D Metabolism is in Chronic Kidney Disease

Eligibility:

MALE

18-85 years

Phase:

NA

Brief Summary

To determine whether or not chronic kidney disease (CKD), stages III-V and ESRD , is associated with altered vitamin D metabolism related to fibroblast growth factor-23 (FGF-23) stimulation of Cyp24 a...

Detailed Description

1. Patients in the Memphis VA Medical Center with documented vitamin D deficiency, determined by measurements of 25(OH)D3, were recruited for this study. 25(OH)D3 measurements are commonly obtained du...

Eligibility Criteria

Inclusion

  • age 18-85 years; CKD stage III or V; serum 25(OH)D level ≤ 30ng/ml, and serum PTH levels \> 70 pg/ml within the last 6 months, informed Consent.

Exclusion

  • A history of liver disease, sarcoidosis, intestinal malabsorption;
  • requirement of dialysis during the study; serum calcium level \>10.5 mg/dl,
  • calcium-phosphorus product \> 70, or
  • calcimimetics, or
  • phosphorus binders; or
  • medications that could affect vitamin D metabolism or
  • history of parathyroidectomy.

Key Trial Info

Start Date :

November 1 2010

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

December 1 2012

Estimated Enrollment :

70 Patients enrolled

Trial Details

Trial ID

NCT01528176

Start Date

November 1 2010

End Date

December 1 2012

Last Update

February 14 2012

Active Locations (1)

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1

Memphis Veteran Affair Medical center

Memphis, Tennessee, United States, 38194