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Status:

RECRUITING

COsegregation of VARiants in Panel of Genes

Lead Sponsor:

Institut Curie

Conditions:

Gene Mutation-Related Cancer

Genetic Predisposition

Eligibility:

All Genders

18+ years

Phase:

NA

Brief Summary

The aim of the COVAR project is to classify reliably a maximum of VUS of the French database in order to use them for the genetic counseling. The results obtained through this study will have a major ...

Detailed Description

Originally, the COVAR study was designed to explore Variants of unknown biological significance (VUS) in BRCA1 (BReast Cancer 1) and BRCA2 (BReast Cancer 2) genes, which are the two major genes identi...

Eligibility Criteria

Inclusion

  • Index cases:
  • A person carrying a gene variant class 3 or 4, present and selected in the families of national database of genetic group and cancer (GGC Unicancer) which identifies the variations of all genes from the panel of genes of all French laboratories.
  • Age ≥ 18 years.
  • Signed written inform consent "index case"
  • Related parties:
  • Any relative of an index case with cancer
  • Any relative without cancer related to an index case, retained by investigators, based on family structure and degree of related compared to the index case
  • Age ≥ 18 years
  • Information and signature of the informed consent "selected relatives"

Exclusion

  • Minors
  • Persons deprived of liberty or under guardianship (including curators).
  • Absence of signed written inform consent

Key Trial Info

Start Date :

July 2 2012

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

January 2 2034

Estimated Enrollment :

3500 Patients enrolled

Trial Details

Trial ID

NCT01689584

Start Date

July 2 2012

End Date

January 2 2034

Last Update

April 6 2025

Active Locations (57)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 15 (57 locations)

1

Institut Curie - Hopital Rene Huguenin

Saint-Cloud, Haut de Seine, France, 92210

2

CHU Amiens - Hôpital Nord

Amiens, France, 80054

3

ICO - Centre Paul Papin

Angers, France, 49933

4

Centre Hospitalier d'Angoulème

Angoulême, France, 16959