Status:
COMPLETED
How Does Dietary Carbohydrate Influence the Formation of an Atherogenic Lipoprotein Phenotype (ALP)?
Lead Sponsor:
Bruce A. Griffin
Collaborating Sponsors:
Imperial College London
University of Cambridge
Conditions:
Non-alcoholic Fatty Liver Disease (NAFLD)
Eligibility:
MALE
18-65 years
Phase:
NA
Brief Summary
The hypothesis of this study is that a diet high in sugars will increase abnormalities in blood lipids which are associated with increased cardiovascular disease risk, relative to a diet which is low ...
Detailed Description
This study aims to determine the metabolic mechanism(s) by which dietary extrinsic sugars (sucrose and fructose), promote the formation of a high risk dyslipidaemia, known as an atherogenic lipoprotei...
Eligibility Criteria
Inclusion
- Male gender,
- Increased cardio-metabolic risk ('RISCK' criteria Jebb et al (2010) Am J Clin Nutr 92, 748-758).
- Apo E3E3 genotype
Exclusion
- Any abnormal result in blood screen (renal and liver function, haematology)
- Diabetes
- Smoker
- Excessive alcohol consumption (\>27units/week)
- Medication likely to affect lipid metabolism
- \>3kg weight loss in preceding 3 months
- Any medical condition (eg. GI tract, allergies) affecting lipid metabolism or ability to comply with dietary interventions
- Involvement in any other study
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT01790984
Start Date
April 1 2009
End Date
September 1 2012
Last Update
May 27 2021
Active Locations (1)
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1
University of Surrey
Guildford, Surrey, United Kingdom, GU2 7XH