Status:
COMPLETED
The Effect of Brown Adipose Tissue Activation on Insulin Sensitivity in Humans
Lead Sponsor:
Rutgers University
Conditions:
Insulin Sensitivity
Obesity
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Recent findings document the presence of active brown adipose tissue (BAT) in humans. Cold exposure via adrenergic stimulation activates BAT, which combusts significant amounts of blood glucose and fr...
Eligibility Criteria
Inclusion
- men or women
- 18-75 years old
- BMI 20-40 kg/m2
Exclusion
- taking diabetes medications
- liver/renal/endocrine/heart disease
- obstructive disease of the gastrointestinal tract
- impaired gag reflex or swallowing disorder
- history of GI surgery or fenilization of esophagus
- GI hypomotility disorder
- cancer
- thyroid or hormone replacement treatment
- beta-blockers
- anabolic or corticosteroids the last 6 mo
- pregnant/lactating women
- individuals that are likely to need PET/CT in the near future for medical reasons
- bleeding disorders/ anemia
- positive hepatitis or HIV screening
- weight less than 36 kg
- pacemaker or other implanted electromedical device
- alcohol and drug abuse
- tobacco use
- impaired cognition
- asthma
- chronic obstructive pulmonary disease (COPD) or other reactive airway diseases
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2018
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT01791114
Start Date
January 1 2012
End Date
December 30 2018
Last Update
March 16 2021
Active Locations (1)
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1
University of Texas Medical Branch at Galveston
Galveston, Texas, United States, 77555