Status:
COMPLETED
Effects of Co-Exposure to Air Pollution and Allergen
Lead Sponsor:
University of British Columbia
Conditions:
Allergies
Eligibility:
All Genders
19-49 years
Phase:
NA
Brief Summary
The investigators are investigating the effects of combined exposures to diesel exhaust and allergens on lung function and on the immune system. After exposing individuals to either filtered air or ca...
Detailed Description
1. Purpose/Objective: To study the effects of diesel exhaust particles on lung function and on allergic responses. 2. Hypotheses: Hypothesis 1: DE exposure augments systemic oxidative stress f...
Eligibility Criteria
Inclusion
- Age between 19 and 49 years.
- Non-smoking.
- Positive skin prick test for at least one of: birch, grass, or dust
Exclusion
- Using inhaled corticosteroids
- Pregnant or planning to be pregnant in the next 12 months / Breastfeeding
- Usage of bronchodilators more than three times per week.
- Co-morbidities (as assessed by the primary investigator)
- Taking part in other studies
- Unwilling to withhold bronchodilator, aspirin, anti-coagulant, antihistamine or decongestant medications or caffeine prior to testing procedures.
- FEV1(Forced expiratory volume in one second) \< 70% predicted.
- Allergy to lidocaine, fentanyl, midazolam or salbutamol.
- Unstable asthma (i.e exacerbation in 2 weeks preceding testing)
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT01792232
Start Date
October 1 2011
End Date
November 1 2013
Last Update
September 29 2017
Active Locations (1)
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1
University of British Columbia
Vancouver, British Columbia, Canada, V5Z 1M9