Status:
COMPLETED
Genetics of Latent Autoimmune Diabetes in Adults
Lead Sponsor:
Children's Hospital of Philadelphia
Conditions:
Latent Autoimmune Diabetes in Adult
Eligibility:
All Genders
25+ years
Brief Summary
This is a prospective study that will study adults and has the objective of examining 'Latent Autoimmune Diabetes in Adults' (LADA) to understand how this trait is influenced by genetic factors.
Detailed Description
A case-control study approach will be used to compare the allelic frequencies of Deoxyribonucleic acid (DNA) markers of the cases (i.e., LADA patients) to a randomly selected control samples that does...
Eligibility Criteria
Inclusion
- Diagnosed type 2 Diabetes (T2D) patient with: BMI \<30 at diagnosis; Age \>25-\<50 at diagnosis
- OR
- Diagnosed type 1 Diabetes (T1D) patient with: Age \>25 at diagnosis
- OR
- \- Currently Diagnosed with LADA with age at initial diagnosis of Diabetes \>25 years and a positive GAD65 antibody test
Exclusion
- Any underlying disease or condition that is a contraindication for obtaining 18.0 ml of blood.
- Inability to obtain an informed consent from a given LADA case.
- Blood sampling has already occurred for a given subject.
- Previous GAD65 antibody test(s) negative.
Key Trial Info
Start Date :
July 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2017
Estimated Enrollment :
205 Patients enrolled
Trial Details
Trial ID
NCT01793974
Start Date
July 1 2011
End Date
March 1 2017
Last Update
April 13 2017
Active Locations (2)
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1
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
2
The University of Leicester
Leicester, United Kingdom