Status:
COMPLETED
Incretin Regulation of Insulin Secretion in Monogenic Diabetes
Lead Sponsor:
University of Chicago
Conditions:
Monogenic Diabetes
Eligibility:
All Genders
18-89 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to explore the mechanisms of metabolic control in monogenic diabetes patients treated with sulfonylurea medications.
Detailed Description
Monogenic diabetes patients and healthy matched controls will be admitted to the University of Chicago Clinical Resource Center for a total of 4 nights. The following will take place on separate days:...
Eligibility Criteria
Inclusion
- Monogenic Diabetes Subjects:
- Diagnosis of monogenic diabetes
- Previously participated in US Neonatal Diabetes Registry (IRB 15617B) or Genetics of diabetes mellitus (IRB 6858)
- Age: 18 years +
Exclusion
- Pregnancy
- Acute medical illness or chronic conditions including: cardiac failure, renal insufficiency (estimated glomerular filtration rate \<50 ml/min), hepatic insufficiency (known cirrhosis or hepatitis), chronic obstructive pulmonary disease, gastrointestinal disorders causing malabsorption, anemia (Hct \< 36%), or uncontrolled hypertension
- Healthy Controls:
- Inclusion Criteria:
- Good general health
- Stable weight for 6 months
- Age: 18 years +
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2017
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01795144
Start Date
January 1 2014
End Date
March 1 2017
Last Update
April 10 2017
Active Locations (1)
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1
University of Chicago
Chicago, Illinois, United States, 60637