Status:
COMPLETED
Circulating Tumor Cells in High-Risk Prostate Cancer Treated With High-dose Radiotherapy and Hormone Therapy
Lead Sponsor:
Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Conditions:
Patients With High-risk Prostate Cancer
Eligibility:
MALE
18+ years
Brief Summary
The detection and quantification of Circulating tumor cells CTCs in peripheral blood of patients with prostate adenocarcinoma may be useful at least for: Getting a correct stratification of patients ...
Detailed Description
Prospective analysis of biologic samples from peripheral blood of 65 patients with localized high-risk PCa (NCCN 2011) treated with RTC-3D-IMRT combined with AD. Following the sign of the informed co...
Eligibility Criteria
Inclusion
- Patients aged \> 18 with capacity to give informed consent.
- Patients with histologically confirmed prostate cancer.
- Patients with a high risk factor: PSA\> 20 ng / ml, Gleason 8-10 and / or stage T3a-b, N0M0 (NCCN 2011, stage IIB-III AJCC classification 2010). Staging by: Histology-Gleason score-, PSA, TR, ECO TR, CT, MRI.
- Patients who accept radical treatment with radiotherapy.
- Patients who give written informed consent to participate in the study
Exclusion
- Any patient diagnosed with prostate cancer, which does not meet the prerequisites.
- Any patients with another malignancy diagnosed in the past 5 years (except basal cell or squamous cell carcinoma of skin).
- Any patient who has prostate biopsy performed 7 days prior to study entry.
- Patients who have received prior treatment with hormonal therapy, chemotherapy or radiotherapy.
- Patients with PSA\> 100 ng / ml.
- Any situation or condition of the patient which in the opinion of the investigator, advised against participation in the study.
Key Trial Info
Start Date :
January 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 21 2018
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT01800058
Start Date
January 1 2014
End Date
December 21 2018
Last Update
June 26 2020
Active Locations (3)
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1
Hospital Universitario de Santiago de Compostela
Santiago de Compostela, La Coruña, Spain, 15706
2
Hospital Universitario de La Princesa
Madrid, Spain, 28006
3
Hospital Universitario 12 de Octubre
Madrid, Spain, 28041