Status:
COMPLETED
The Effects of Acute Total Sleep Deprivation Versus Normal Sleep on Metabolism
Lead Sponsor:
Uppsala University
Conditions:
Sleep Deprivation
Sleep
Eligibility:
MALE
18-28 years
Phase:
NA
Brief Summary
The study proposes to investigate whether acute total deprivation affects metabolism as measured through blood and peripheral tissues. Its aim is also to investigate how acute total sleep deprivation ...
Detailed Description
It is predicted that acute total sleep deprivation will affect gene expression and DNA methylation. It is also predicted that sleep deprivation will up-regulate ghrelin, and affect other neuroendocrin...
Eligibility Criteria
Inclusion
- Male
- Age 18-28y
- Healthy (self-reported) and not on medication
- Non-smoking
- Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported via diaries)
Exclusion
- Major illness
- Taking any serious medications
- Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
- Any dietary issues with the food items provided
- Current or history of endocrine, neurological or psychiatric disorders
- Shift work in the preceding three months or for a long duration
- Time travel over a significant number of time zones in the preceding two months
- Too much weight gain or weight loss in the preceding three months
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT01800253
Start Date
March 1 2013
End Date
October 1 2013
Last Update
December 9 2013
Active Locations (1)
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1
Department of Neuroscience, Uppsala University
Uppsala, Uppsala County, Sweden, 75324