Status:
UNKNOWN
Endometrial Biopsy Prior to IVF in Those Patients With Prior Implantation Failure
Lead Sponsor:
Shady Grove Fertility Reproductive Science Center
Conditions:
Implantation Failure
Infertility
Eligibility:
FEMALE
18-37 years
Phase:
NA
Brief Summary
This proposed research is a single center, prospective, single-blinded, randomized controlled trial, designed to evaluate IVF pregnancy outcomes following endometrial injury in 254 patients with impla...
Detailed Description
Despite advances in assisted reproductive technologies; implantation failure in patients undergoing in-vitro fertilization (IVF) is frequent. Unfortunately, few treatments exist except for the use of ...
Eligibility Criteria
Inclusion
- Women age 18-37
- One or more previous implantation failures with autologous fresh or frozen blastocyst transfer
- Undergoing fresh autologous IVF cycle
- No other current uterine (i.e.: uterine fibroids, polyps), hematologic, or genetic causes for infertility and implantation failure
- One or more good quality blastocyst(s) available for transfer
Exclusion
- Those unable to comprehend the investigational nature of the proposed study
- Positive pregnancy test
- Possible causes for impaired implantation (systemic disease, endometriosis, ultrasound evidence of current hydrosalpinx, uterine polyps, uterine myomas (fibroids), uterine cavity malformations or Asherman's syndrome)
- Poor responders, defined as FSH \>12 on day 3 or less than 4 follicles on a previous IVF cycle
- BMI \>30 or \<18
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
254 Patients enrolled
Trial Details
Trial ID
NCT01800513
Start Date
February 1 2013
End Date
December 1 2015
Last Update
February 27 2013
Active Locations (1)
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1
Shady Grove Fertility Reproductive Science Center
Rockville, Maryland, United States, 20850