Status:

COMPLETED

Predicting Cognitive and Emotional Health From Neurocircuitry Following TBI

Lead Sponsor:

University of Arizona

Collaborating Sponsors:

United States Department of Defense

Conditions:

Traumatic Brain Injury

Eligibility:

All Genders

20-45 years

Brief Summary

Abnormalities in structural and functional connectivity between brain regions have been suggested as putative biomarkers of mild traumatic brain injury (TBI) and significant contributors to neuropsych...

Eligibility Criteria

Inclusion

  • English as first language
  • Ability to provide informed consent
  • For TBI group: documented TBI experienced within 12 months prior to testing.

Exclusion

  • Metal within the body, claustrophobia or other contraindications for MRI
  • Complicating medical conditions that may influence the outcome of neuropsychological assessment or neuroimaging (e.g., HIV, brain tumor, etc.)
  • Less than 9th grade education
  • History of alcoholism or substance use disorder
  • Excess current alcohol use or illicit substance use
  • for Healthy Controls (HC): life-time history of TBI or Axis I disorder
  • Pregnancy (ruled out by urine β-HCG)
  • Colorblindness
  • for HC: Having participated in a sport with a high risk of concussive/subconcussive blows for a period of at least 1 month including but not limited to: football, rugby, boxing, ice hockey, wrestling, soccer, martial arts

Key Trial Info

Start Date :

February 1 2013

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

December 1 2019

Estimated Enrollment :

190 Patients enrolled

Trial Details

Trial ID

NCT01803048

Start Date

February 1 2013

End Date

December 1 2019

Last Update

November 4 2020

Active Locations (1)

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1

University of Arizona Psychiatry Department

Tucson, Arizona, United States, 85724