Status:
COMPLETED
Skeletal Muscles, Myokines and Glucose Metabolism MYOGLU
Lead Sponsor:
Oslo University Hospital
Collaborating Sponsors:
University of Oslo
Norwegian School of Sport Sciences
Conditions:
Hyperglycemia
Normoglycemia
Eligibility:
MALE
40-65 years
Phase:
NA
Brief Summary
Normal glucose uptake and metabolism in skeletal muscles are essential to keep blood glucose within normal range and hence, insulin resistance (possibly mediated by inflammatory processes) in skeletal...
Eligibility Criteria
Inclusion
- Male
- Age 40-65 years
- Nordic ethnicity
- Non-smoker
- Either (participants with impaired glucose metabolism): Body Mass Index (BMI) 27-32 kg/m2 and abnormal glucose metabolism, defined as:
- i. impaired fasting glucose (FPG ≥ 5.6 mmol/L) ii. impaired glucose tolerance (2 h PG ≥7.8 mmol/L) iii. type 2 diabetes (no medication, HbA1c ≤7.5%)
- Or (controls): BMI 19-25 kg/m2 and normal glucose metabolism and no first degree relatives with type 2 diabetes.
Exclusion
- Subjects having type 1 diabetes or medically treated type 2 diabetes.
- Systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 90 mmHg at screening
- Significant hematological or renal disease or chronic renal impairment, GFR\< 50 ml/min.
- Significant liver disease or ALAT \>3x UNL.
- Chronic inflammatory disease in active phase or long-term use of corticosteroids last 3 months.
- Use of anti-diabetic agents, lipid lowering drugs, antihypertensive medication, ASA or any other drug not deemed suitable by the study physician.
- Mental condition (psychiatric or organic cerebral disease), drug or alcohol abuse rendering the subject unable to understand the nature, scope and possible consequences of the study.
- BMI outside inclusion criteria.
- Smoker
- Any medical or other condition that in the judgment of the investigator would jeopardize the subject's safety or evaluation of the intervention for efficacy and safety
- Exercising regularly (\>1 times pr week)
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT01803568
Start Date
September 1 2011
End Date
December 1 2012
Last Update
March 4 2013
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