Status:
UNKNOWN
Lactulose and Glucose Breath Tests as Predictors of Clinical Benefit From Rifaximin in Irritable Bowel Syndrome
Lead Sponsor:
Pontificia Universidad Catolica de Chile
Conditions:
Irritable Bowel Syndrome
Eligibility:
All Genders
18-80 years
Brief Summary
The Irritable Bowel Syndrome (IBS) is a frequent disease, affecting between 10 and 20% of general population. Several pathophysiologic mechanisms have been described in IBS, among them the role of int...
Detailed Description
After signing the informed consent, all patients will be submitted to both glucose and lactulose breath tests within a 10 days period. The order of the test will be randomized using a random number li...
Eligibility Criteria
Inclusion
- Patients meeting Rome III criteria for IBS.
Exclusion
- Patients \< 18 years old
- Previous intestinal (small or large bowel) resection
- Known anatomical intestinal alterations, including diverticula and stenosis
- Inflamatory bowel disease (Crohn´s or ulcerative colitis)
- Presence of IBS alarm signs suggestive of organic disease, including anemia or family history of celiac disease or colon cancer
- Recent acute onset diarrhea
- Pregnancy
- Neurologic or psychiatric disease that may not allow the patient to appropriately describe clinical outcomes
- Presence of a disease that could affect intestinal transit, such as Parkinson´s, Chronic Intestinal Pseudobstruction, Scleroderma, Diabetes mellitus, etc
- Impossibility to transitory withdraw drugs that affect intestinal transit, such as Calcium channel blockers, tricyclics
- Inability to sign or rejection to informed consent
Key Trial Info
Start Date :
May 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2014
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01803724
Start Date
May 1 2013
End Date
December 1 2014
Last Update
March 4 2013
Active Locations (1)
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1
Department of Gastroenterology, Pontificia Universidad Catolica de Chile
Santiago, Metropolitan, Chile, 8330024