Status:
COMPLETED
MRI and Mammography Before Surgery in Patients With Stage I-II Breast Cancer
Lead Sponsor:
Alliance for Clinical Trials in Oncology
Collaborating Sponsors:
National Cancer Institute (NCI)
American College of Radiology Imaging Network
Conditions:
Estrogen Receptor-negative Breast Cancer
Progesterone Receptor-negative Breast Cancer
Eligibility:
FEMALE
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to test whether patients undergoing a breast MRI (magnetic resonance imaging) before breast surgery will have better results after the surgery. Breast tumors are routinely...
Detailed Description
This is a randomized trial of preoperative breast MRI in patients deemed eligible for breast conserving surgery by conventional clinical criteria will provide important information about the clinical ...
Eligibility Criteria
Inclusion
- Female. Men are excluded from this study because the number of men with breast cancer is insufficient to provide a statistical basis for assessment of effects in this subpopulation of people with breast cancer.
- Pathologically confirmed diagnosis of breast cancer, clinical stage I-II (T1-3 N0 M0, T0-2 N1 M0). Diagnosis must be by needle biopsy; patients diagnosed by surgical excision are excluded.
- Patients must have either:
- Estrogen receptor (ER) negative/progesterone receptor (PR) negative (\< 10% by immunohistochemistry IHC staining) and HER-2 negative breast cancer OR
- ER negative/PR negative (\< 10% by IHC staining) and HER-2 positive tumors
- HER-2 status will be determined as per the 2013 ASCO CAP guidelines:
- HER-2 is considered positive if there is IHC 3+ staining or ISH positive using either single probe ISH or dual probe ISH
- HER-2 is considered negative if there is IHC 0 or 1+ staining or ISH negative using either single probe ISH or dual probe ISH
- No patients with previous ipsilateral invasive breast cancer or ductal carcinoma in situ (DCIS)
- No patients with bilateral breast cancer
- No patients with known deleterious mutations in breast cancer (BRCA) genes
- No current history of receiving hormonal therapy, tamoxifen, and or aromatase inhibitors for therapeutic measures
- No history of chemotherapy for cancer within 6 months prior to registration
- No patients scheduled to receive neoadjuvant chemotherapy or partial breast irradiation following breast conserving surgery
- Eligible for BCT based on clinical examination, mammography and, if standard practice at a given institution, ultrasound and/or tomogram. Women who cannot be appropriately selected for BCT based on these standard imaging studies, and for whom additional imaging is recommended to clarify local disease extent, will not be eligible for this trial.
- No patients with multicentric or multifocal disease scheduled to undergo multiple lumpectomies. Multifocal disease that can be encompassed in a single operative bed can be enrolled.
- Suitable to undergo MRI and receive the contrast agent gadolinium (exclusions follow):
- No history of untreatable claustrophobia
- No presence of metallic objects or implanted medical devices in body (i.e., cardiac pacemaker, aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, tattoos near the eye, or steel implants)
- No history of sickle cell disease
- No contraindication to intravenous contrast administration
- No known allergy-like reaction to gadolinium or moderate or severe allergic reactions to one or more allergens as defined by the American College of Radiology (ACR); patient may be eligible if willing to undergo pre-treatment as defined by the institution's policy and/or ACR guidance
- No findings consistent with renal failure, as determined by glomerular filtration rate (GFR) \< 30 mL/min/1.73 m\^2 based on a creatinine level obtained within 28 days prior to registration
- Weight lower than that allowable by the MRI table
- No prior MRI of study breast within the 12 months prior to registration
- Non-pregnant and non-lactating. Patients of child-bearing potential must have a negative pregnancy test within 7 days prior to registration. Perimenopausal patients must be amenorrheic \> 12 months to be considered not of child-bearing potential
- ≥ 18 years of age
- Signed study-specific informed consent prior to registration
Exclusion
Key Trial Info
Start Date :
May 21 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 27 2025
Estimated Enrollment :
317 Patients enrolled
Trial Details
Trial ID
NCT01805076
Start Date
May 21 2014
End Date
May 27 2025
Last Update
September 5 2025
Active Locations (179)
Enter a location and click search to find clinical trials sorted by distance.
1
Banner MD Anderson Cancer Center
Gilbert, Arizona, United States, 85234
2
Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States, 72401
3
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, United States, 94531
4
Enloe Medical Center
Chico, California, United States, 95926