Status:
COMPLETED
Laryngeal and Esophageal EGF-r Expression in Patients With Reflux Laryngitis
Lead Sponsor:
Faculdade de Ciências Médicas da Santa Casa de São Paulo
Conditions:
Gastroesophageal Reflux Disease
Chronic Laryngitis
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
* Saliva plays an important role in the homeostasis of the digestive tract mucosa. * Salivary organic components, such as the Epidermal Growth Factor(EGF) have been found in defficient concentrations ...
Detailed Description
Objectives: The expression of the Epidermal Growth Factor receptor (EGFR) has been studied in a number of neoplastic and chronic diseases, but there are no reports in literature regarding its expressi...
Eligibility Criteria
Inclusion
- Adults with reflux laryngitis diagnosed by clinical symptoms (Reflux Symptom -Index \>13) and videolaryngoscopic signs (Reflux Finding Score \>7)
- A positive 24-hour doube probe esophageal ph monitoring test
Exclusion
- Other known causes of chronic laryngitis or inflammatory conditions of the pharynx, larynx and upper digestive tract.
- Current or past history of Head and Neck or digestive tract tumors.
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2007
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT01806220
Start Date
January 1 2004
End Date
December 1 2007
Last Update
March 20 2015
Active Locations (1)
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1
Santa Casa School of Medicine and Hospitals of São Paulo Brazil
São Paulo, São Paulo, Brazil, 01222-010