Status:
COMPLETED
CHO(E)P-14 Followed by Alemtuzumab Consolidation in Peripheral T Cell Lymphoma
Lead Sponsor:
University of Göttingen
Conditions:
Peripheral T-Cell Lymphoma
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
Prospective Phase II Study for Treatment Peripheral T-cell Lymphoma, CHOP-14 Plus PEG-Filgrastim Followed by Alemtuzumab Consolidation
Detailed Description
Peripheral T cell lymphoma patients of all subtypes according to WHO are treated with an induction of 6 cycles of CHOP-etoposide-14 (if below 60 years of age) oder CHOP-14. If at least a PR is reached...
Eligibility Criteria
Inclusion
- all risk groups in international prognostic index
- diagnosis of aggressive T-cell-lymphoma, confirmed by an excisional biopsy of a lymph node or by sufficiently extensive biopsy of an extranodal involvment, if there is no lymph node involvment.
- these lymphomas comprise: peripheral T-cell lymphoma PTCL-NOS Lennert´s lymphoma T-zone lymphoma angioimmunoblastic T-cell-lymphoma
- Performance status: ECOG (Eastern Cooperative Oncology Group Score) 0-3(Karnofsky index 40-100%)
- written consent of the patient
- Declaration of center participation
Exclusion
- Already initiated lymphoma therapy(exept for the prephase treatment specified for this study)
- Serious accompanying disorder or impaired organ function
- bone marrow involvement\>25%
- Known hypersensitivity to medications to be used
- Know HIV-positivity
- Active hepatitis infection, active CMV infection, prior florid tuberculosis
- floride systemic infections
- suspicion that patient compliance will be poor
- Simultaneous participation in any the study protocol
- prior chemo-or radiotherapy for malignancy
- other concomitant malignant disease
- Pregnancy or lactation period
Key Trial Info
Start Date :
July 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2011
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT01806337
Start Date
July 1 2003
End Date
February 1 2011
Last Update
March 7 2013
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.