Status:
COMPLETED
Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction
Lead Sponsor:
Sun Yat-sen University
Collaborating Sponsors:
First Affiliated Hospital, Sun Yat-Sen University
Third Affiliated Hospital, Sun Yat-Sen University
Conditions:
Intra-abdominal and Intrapelvic Surgery
Eligibility:
All Genders
60-100 years
Phase:
PHASE4
Brief Summary
Post-operative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon. Most patients will receive general anesthesia during surgery. Two groups of general anesthetics are used fo...
Detailed Description
Patients who are 60 years old or older for laparoscopic abdominal surgery will be randomly assigned into two groups: 1) sevoflurane-based general anesthesia group, and 2) propofol-based general anesth...
Eligibility Criteria
Inclusion
- major elective gastrointestinal, gynecological, prostate or bladder surgery patients who are ≥ 60 years old.
- the surgery is laparoscopic surgery and is expected to last for ≥ 2 hours under general anesthesia and the patient will stay in hospital for at least 7 days after surgery.
- lack of serious hearing and vision impairment and be able to read so that neurobehavioral tests can be performed.
Exclusion
- Patients are not expected to be alive for longer than 3 months.
- Mini-mental State Examination (MMSE) \[18\] score ≤ 23.
- history of dementia, psychiatric illness or any diseases of central nervous system.
- current use of sedatives or antidepressant.
- alcoholism and drug dependence.
- patients previously included in this study (for patients who have second intra-abdominal surgery during the study period).
- difficult to follow up or patients with poor compliance.
- uncontrolled hypertension (\> 180/100 mmHg)
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2019
Estimated Enrollment :
684 Patients enrolled
Trial Details
Trial ID
NCT01809041
Start Date
March 1 2013
End Date
April 1 2019
Last Update
June 22 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Sun Yat-Sen Memorial Hospital
Guangzhou, Guangdong, China, 510120