Status:
TERMINATED
Safety of Platelet Transfusion in Patients on Antiplatelet Therapy With Traumatic Head Injury
Lead Sponsor:
Christiana Care Health Services
Collaborating Sponsors:
United States Department of Defense
Conditions:
Traumatic Head Injury
Intracranial Hemmorhage
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this study is to determine if the administration of platelets will improve outcome in patients with ICH who are being treated with either aspirin, a thienopyridine (ticlodipine, clopi...
Detailed Description
Intracranial hemorrhage (ICH), or bleeding in the brain, is the major cause of death in trauma patients. The initial volume and early growth of the hematoma are critical determinants of mortality and ...
Eligibility Criteria
Inclusion
- 18 years or older
- Evidence of intracranial hemorrhage (bleeding in the brain) by CT scan related to traumatic injury
- Receiving antiplatelet therapy such as aspirin, thienopyridine (ticlopidine, clopidogrel, or prasugrel)
- Platelet count greater than or equal to 100,000
Exclusion
- Glasgow Coma Scale (GCS) less than 6
- Hemorrhage requiring emergent surgery
- Lack of permission from treating physician and/or consultant
- Secondary ICH related to aneurysm or arteriovenous malformation
- Use of oral anticoagulants
- Decreased platelets (thrombocytopenia)
- Patients requiring massive transfusion protocol
- Life expectancy less than 3 months
- Confirmed acute heart attack
- Hepatitis and liver cirrhosis
- Kidney failure
- Participation in another treatment study within the preceding 30 days
Key Trial Info
Start Date :
June 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2013
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01810276
Start Date
June 1 2012
End Date
April 1 2013
Last Update
April 18 2017
Active Locations (1)
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1
Christiana Care Health System, Christiana Hospital
Newark, Delaware, United States, 19718