Status:
COMPLETED
Role of Interleukin-1 in Postprandial Fatigue - The Cheesecake Study
Lead Sponsor:
University of Zurich
Conditions:
Postprandial Fatigue
Eligibility:
MALE
20-50 years
Phase:
PHASE1
Brief Summary
The aim of the study is to investigate, if postprandial fatigue symptoms after ingestion of a high-fat, high-carbohydrate meal are regulated by Interleukin (IL)-1 and can be prevented by inhibition of...
Eligibility Criteria
Inclusion
- male
- non-smoking
- apparently healthy
- BMI \>18 and ≤25 kg/m2
- Age 20-50 years
- Willingness to use contraceptive measures adequate to prevent the subject's partner from becoming pregnant during the study. Adequate contraceptive measures include hormonal methods used for two or more cycles prior to screening (e.g., oral contraceptive pills, contraceptive patch, or contraceptive vaginal ring), double barrier methods (e.g., contraceptive sponge, diaphragm used in conjunction with contraceptive foam or jelly, and condom used in conjunction with contraceptive foam or jelly), intrauterine methods (IUD), sterilization (e.g., tubal ligation or a monogamous relationship with a vasectomized partner), and abstinence.
Exclusion
- Clinical signs of infection in the week before inclusion or history of infection during the last 2 months (CRP \>5mg/l)
- Impaired fasting glucose (fasting plasma glucose \>5.5mmol/l)
- Hematologic disease (leukocyte count \< 1.5x109/l, hemoglobin \<11 g/dl, platelets \<100 x 103/ul)
- Kidney disease (creatinine \> 1.5 mg/dL))
- Liver disease (transaminases \>2x upper normal range)
- Heart disease
- Pulmonary disease
- Inflammatory disease
- History of carcinoma
- History of tuberculosis
- Alcohol consumption \>40g/d
- Smoking
- Known allergy towards Anakinra
- Known allergy towards ingredients of the test meal
- Current treatment with any drug in the week before inclusion, including vitamin supplementation (especially vitamin C and E)
- Use of any investigational drug within 30 days prior to enrollment or within 5 half-lives of the investigational drug, whichever is longer
- Subject refusing or unable to give written informed consent
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01810549
Start Date
March 1 2013
Last Update
December 17 2014
Active Locations (1)
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1
University Hospital Basel
Basel, Switzerland, 4031