Status:
COMPLETED
Moderate to Severe Bronchiolitis: Standard Therapy Versus Therapy With NaCl 3% Inhalations
Lead Sponsor:
Raphaelle Jaquet-Pilloud
Collaborating Sponsors:
Swiss Foundation for the Health of Children and Adolescents
Conditions:
Moderate to Severe Bronchiolitis
Eligibility:
All Genders
6-24 years
Phase:
PHASE3
Brief Summary
Our study will investigate inhalation therapy of NaCl 3% compared to standard therapy with no inhalation in the treatment of moderate to severe bronchiolitis. The impact on length of hospital stay wil...
Detailed Description
Acute viral bronchiolitis is the most common lower respiratory tract infection in the first year of life and leads to a large number of hospital admissions. The only recommended treatment is supportiv...
Eligibility Criteria
Inclusion
- children between ages 6 weeks to 24 months
- first episode of wheezing
- diagnosis of moderate to severe bronchiolitis: The patients are ranked as moderately to severely ill according to the Wang clinical severity score
Exclusion
- Children with mild bronchiolitis (Wang score \< 5)
- Children with pre-existent cardiac disease
- Children with clinically significant chronic respiratory disease
- Immunocompromised children
- Children with a gestational age at birth less than 34 weeks
- Children who received immunoprophylaxis therapy (i.e RSV immune globulin therapy)
- Children who received corticosteroid in any form in the preceding 2 weeks before presentation
- Children who received bronchodilators within 24 hours before presentation
- Children with critical illness at presentation requiring immediate admission to intensive care unit
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2016
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01812525
Start Date
March 1 2013
End Date
April 1 2016
Last Update
August 19 2016
Active Locations (1)
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1
Hôpital de l'Enfance
Lausanne, Canton of Vaud, Switzerland, 1000