Status:
COMPLETED
Angiogenesis and Fibrosis in Myocardial Infarction
Lead Sponsor:
University of Edinburgh
Conditions:
Myocardial Infarction
Fibrosis
Eligibility:
All Genders
40+ years
Brief Summary
Angiogenesis and fibrosis lie at the heart of a number of fundamental processes responsible for cardiovascular disease. In this proposal, the investigators intend to build upon a highly successful pro...
Detailed Description
Integrins are a group of molecules responsible for intercellular adhesion and signalling. They comprise a superfamily of heterodimeric receptors that are composed of 18 different α and β subunits. In ...
Eligibility Criteria
Inclusion
- Patients will be recruited if they are \>40 years of age and have sustained a recent large (plasma troponin I concentration \>10 ng/mL; upper limit of normal 0.05 ng/mL) acute myocardial infarction defined according to the Universal Definition of myocardial infarction \[Thygesen et al, 2007\].
- We will recruit patients with a major epicardial occlusion that has or has not been revascularised with percutaneous coronary intervention (n=15 per group). We will also recruit 10 patients with an angiographically documented chronic (\>6 months) proximal coronary artery occlusion that has not been revascularised but has extensive collateral coronary blood flow.
Exclusion
- A known critical (≥95%) left main stem coronary artery stenosis
- Continued symptoms of angina at rest or minimal exertion
- Atrial fibrillation
- Hepatic failure (Childs-Pugh grade B or C)
- Renal failure (estimated glomerular filtration rate \<25 mL/min)
- Women of child-bearing potential.
- Inability to undergo scanning
- Contraindication to magnetic resonance imaging
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01813045
Start Date
April 1 2013
End Date
March 1 2016
Last Update
August 30 2016
Active Locations (1)
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1
University of Edinburgh
Edinburgh, Lothian, United Kingdom, EH16 4TJ