Status:
COMPLETED
Ischemic Postconditioning in Cardiac Surgery
Lead Sponsor:
Oslo University Hospital
Collaborating Sponsors:
Medical University of Warsaw
University Hospital of North Norway
Conditions:
Cardiac Surgery
Eligibility:
All Genders
20+ years
Phase:
NA
Brief Summary
Ischemic postconditioning by repetitive cycles of reperfusion and ischemia has been proven both in animal models and in humans. This study aims to investigate the effect of ischemic postconditioning o...
Detailed Description
Ischemic postconditioning is studied using cardiopulmonary bypass (CPB) and moderate hypothermia (32-34°C) in a patient population undergoing surgery of the aortic valve (repair/replacement ) or the a...
Eligibility Criteria
Inclusion
- Patients undergoing elective surgery of the ascending aorta or the aortic valve
- \-
Exclusion
- Coronary artery disease requiring bypass surgery
- Tricuspid valve surgery
- Mitral valve surgery
- Atrial fibrillation (permanent or paroxysmal with or without concomitant ablation procedure)
- Patients on per oral or parenteral steroid therapy (inhalational steroids are allowed)
- Patients with autoimmune diseases
- "Redo" operations
- Active endocarditis (ongoing antibiotic therapy)
- On the discretion of the operating surgeon or anaesthesiologist
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 5 2018
Estimated Enrollment :
209 Patients enrolled
Trial Details
Trial ID
NCT01813968
Start Date
January 1 2013
End Date
June 5 2018
Last Update
December 15 2023
Active Locations (1)
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1
Department of Cardiothoracic Surgery, Oslo University Hospital, Ullevål
Oslo, Norway, 0424