Status:
COMPLETED
The Effect of High and Low Roasted Coffee on Vascular Response
Lead Sponsor:
University of Reading
Conditions:
Cardiovascular Disease
Eligibility:
MALE
19-35 years
Phase:
NA
Brief Summary
Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level o...
Eligibility Criteria
Inclusion
- Male
- A signed consent form
- Age 19-35 years
- Body mass index - 18.5-30 kg/m2
- Normal blood pressure at screening (\< 150/90)
Exclusion
- Blood pressure \> 150/90 mmHg
- Haemoglobin (anaemia marker) \< 125 g/l
- Gamma GT (liver enzymes) \> 80 IU/l
- Cholesterol \> 6.5 mmol/l
- Had suffered a myocardial infarction or stroke in the previous 12 months
- Suffers from any reproductive disorder
- Suffers from any blood-clotting disorder
- Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
- Any dietary restrictions or on a weight reducing diet
- Drinking more than 21 units per week
- On any lipid-modifying medication
- On any blood pressure lowering medication
- On any medication affecting blood clotting
- Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study
- Regular or vigorous exercise (3 times/week, 20 minutes each session)
- Smoking
- Vegetarians or vegans
Key Trial Info
Start Date :
May 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT01813981
Start Date
May 1 2011
End Date
January 1 2013
Last Update
March 19 2013
Active Locations (2)
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1
Department of Food and Nutritional Sciences
Reading, Berkshire, United Kingdom, RG6 6AP
2
University of Reading
Reading, England, United Kingdom, RG6 6UR