Status:
COMPLETED
Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope
Lead Sponsor:
Policlinico Casilino ASL RMB
Conditions:
Neuromediated Cardioinhibitory Syncope
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Cardioinhibitory neurocardiogenic syncope (CNS) or vasovagal syncope, is the most frequent aetiology of syncope in young people without apparent cardiac or neurological pathology. It is usually caused...
Eligibility Criteria
Inclusion
- Twenty consecutive patients affected by cardioinhibitory neurocardiogenic syncope will be enrolled in the study.
- Inclusion criteria:
- age between 18 and 60 years
- 3 syncopal episodes at least of likely CNS in the previous 2 years
- marked cardioinhibitory response to HUT or documented asystolic pauses at internal loop recorder registration \[7\].
- Cardioinhibition will be considered as elicitation of asystolic pause (sinus arrest or AV block) ≥ 3 seconds associated to syncope or ≥ 6 seconds and related presyncope.
- Exclusion criteria:
- documented myocardial and/or valvular abnormalities on 2D echocardiogram (ejection fraction lower than 50%)
- documented tachyarrhythmias as possible causes of symptoms
- channelopathies (Brugada syndrome, LQT or SQT syndrome)
- ventricular preexcitation
- symptomatic orthostatic hypotension diagnosed by standing blood pressure measurement
- pregnancy in women
- previous cardiac pacemaker implantation.
Exclusion
Key Trial Info
Start Date :
September 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01814228
Start Date
September 1 2013
End Date
April 1 2020
Last Update
April 27 2020
Active Locations (1)
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1
Policlinico Casilino
Rome, Lazio, Italy, 00169