Status:
COMPLETED
Interactive Effects of IV Ethanol and IV Nicotine
Lead Sponsor:
Yale University
Collaborating Sponsors:
South Central VA Mental Illness Research, Education & Clinical Center
Conditions:
Healthy
Eligibility:
All Genders
21-50 years
Phase:
EARLY_PHASE1
Brief Summary
There are mixed reports on nicotine's effects on ethanol-induced impairment in cognitive performance and behavior in humans. The main objective of this study is to characterize the interactive effects...
Eligibility Criteria
Inclusion
- Male and female;
- between the ages of 21 and 50 years;
- medically and neurologically healthy on the basis of history, physical examination, EKG, screening laboratories
- history of smoking daily for the past 12 months, at least 5 cigarettes daily; not seeking treatment for nicotine dependence
- social drinkers no maximum level of alcohol consumption will be defined a priori but individuals who met current DSM -IV criteria for alcohol dependence (abuse will be allowed) will be excluded from the study.
Exclusion
- history of major medical illnesses that the physician investigator deems as contraindicated for the patient to be in the study;
- regular use of psychotropic medication (antidepressants, antipsychotics, or anxiolytics) and recent psychiatric diagnosis and treatment for Axis I disorders including major depression, bipolar affective disorder, schizophrenia or panic disorder;
- current abuse of any recreational or prescription drugs (except alcohol);
- alcohol naïve.
Key Trial Info
Start Date :
February 22 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT01814410
Start Date
February 22 2013
End Date
June 1 2014
Last Update
January 17 2018
Active Locations (1)
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1
West Haven VA Hospital
West Haven, Connecticut, United States, 06516