Status:
UNKNOWN
Revitalization of Immature Permanent Teeth With Necrotic Pulps Using SHED Cells
Lead Sponsor:
Air Force Military Medical University, China
Conditions:
Dental Pulp Necrosis
Permanent Incisor Avulsed by Trauma
Eligibility:
All Genders
7-12 years
Phase:
NA
Brief Summary
Revitalization of Young Immature Permanent Teeth With Necrotic Pulps Using Autologous Stem Cells from Human Exfoliated Deciduous Teeth
Detailed Description
Irreversible damage to immature permanent teeth as a result of noxious infection or local trauma before normal physiological closure of the apical structure represents a real clinical challenge. The c...
Eligibility Criteria
Inclusion
- Those who has signed the informed consent.
- Those who are between 7-years-old to 12-years-old.
- Those with at least one young permanent teeth with pulp necrosis which caused by trauma or permanent incisor avulsed by trauma.
- Those who can provide the health deciduous teeth.
- Those who have accomplished initial preparation and have been showing good compliance.
- Those whose guardians understand the purposes of the trial and are capable of making an independent decision to comply with trial requirements
- Those who are able to visit our hospital in accordance with the trial schedule
Exclusion
- Those in an extremely poor nutritional condition (serum albumin concentration \<2 g/dL)
- Those whose guardians would not cooperate with the treatment.
- Those who has uncontrollable oral disease.
- Those with severe dental fear.
- Those with coexisting mental or consciousness disorder.
- Those with teeth dysplasia and/or hereditary disease history.
- Those with systemic disease which may affect the postoperative healing.
- Those with bruxism and malocclusion.
- Loss of the avulsed teeth.
- Those who are taking the medicine which would affect the postoperative healing.
- Those with the bad oral habits.
- Those who are undertaking other trail meanwhile or few weeks ago.
- Those coexisting disease of the blood or immune system.
- Those who are not capable to provide the deciduous dental pulp cells.
- Those with the severe tooth trauma (crown-root or root fracture, tooth displacement).
- Others who the investigators or sub-investigators determined as unsuitable for the trial.
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2017
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT01814436
Start Date
February 1 2013
End Date
October 1 2017
Last Update
April 28 2016
Active Locations (1)
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1
School of Stomatology, Fourth Military Medical University
Xi'an, Shaanxi, China, 710032