Status:
TERMINATED
Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging
Lead Sponsor:
Centre Hospitalier Universitaire, Amiens
Conditions:
Alzheimer Disease
Mild Cognitive Impairment
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
The physio-pathology of Alzheimer's disease (AD) remains unknown and there is no cure. Thus, the search for objective markers of preclinical first signs of cognitive impairment, is currently a major p...
Eligibility Criteria
Inclusion
- Age: over 65
- Participants (or representatives) gave their written informed consent
- Dementia diagnosed according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) criteria
- For Alzheimer arm: probable Alzheimer based disease according to NINCDS-ADRDA (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association ) criteria
- For vascular dementia: diagnosis based on NINDS-AIREN (National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et l'Enseignement en Neurosciences) criteria
- For MCI: diagnosis based on Petersen index
Exclusion
- Claustrophobia
- Diabetes
- Cardiovascular disease
- Glycemia over 1.3 g/L
- Lumbar puncture within one week before MRI examination
- Non MR-compatible implant
- Suspected brain metastases
- No informed consent signature
Key Trial Info
Start Date :
February 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2014
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01815112
Start Date
February 1 2008
End Date
April 1 2014
Last Update
March 10 2015
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
CHU Rouen
Rouen, Haute Normandie, France, 76000
2
CHU Amiens
Amiens, Picardie, France, 80054